WTDWTR (What To Do With This Reaction ?) is an improved version of the old SCORE program.
If we consider the syntheses published in the literature one can remark that a method largely used is to start from a given reaction : the chemist is familiar with a particular reaction (Diels-Alder, radical cascade, [2+2+2], de Mayo, etc.) and he searches for a structure in which it is possible to apply this reaction as the key-step in its synthesis.
WTDWTR is a new program in the field of computer-aided organic synthesis, it tries to answer to the following question : what kind of structures is it possible to obtain from a given reaction ?
Since cyclic structures are among the most important in organic chemistry, the aim of WTDWTR is to generate the cyclic structures which correspond to a given reaction. In a first approach only carbocyclic structures are generated.
WTDWTR was tested with the Diels-Alder reaction in the case of structures possessing four rings of size 6, 6, 6, 5 (“isomers” of steroid skeleton) for which WTDWTR generated 590 solutions.

30 - SCORE : a program to explore the SCOpe a given intramolecular REaction. How to find systematically the relevancy of a transform to various classes of structures. Application to the de Mayo reaction.
R. Barone, M. Arbelot and M. Chanon.
Tetrahedron Computer Methodology, 1988, 1, 3-14.

55 – WTDWTR : What To Do With This Reaction ?
R. Barone, M. Attolini, M. Arbelot, M. Chanon
Europ. J. Org. Chem., 2006, 22, 5184-5190.

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